Kechagias Nikos, Ntomouchtsis Aris, Valeri Rosalia, Patrikidou Anna, Kitikidou Kyriaki, Xirou Persefoni, Destouni Chareklia, Vahtsevanos Konstantinos, Antoniades Konstantinos
Department of Oral and Maxillofacial Surgery, Theagenion Cancer Hospital, 2 Al. Simeonidi Street, 540 07 Thessaloniki, Greece.
Oral Maxillofac Surg. 2012 Mar;16(1):35-40. doi: 10.1007/s10006-011-0291-8. Epub 2011 Sep 6.
The aim of this study was to evaluate the sensitivity, specificity, diagnostic accuracy, positive predictive value (PPV) and negative predictive value (NPV) of fine-needle aspiration cytology (FNAC) of salivary gland tumours performed at a tertiary cancer hospital over a time period of 10 years.
A retrospective analysis was carried out between 1995 and 2004 to review the cases of patients with salivary gland tumours who had undergone pre-operative FNA and for whom definite histology was either by tru-cut biopsy or by histopathological examination of the operative specimen.
A total of 107 cases of salivary gland tumours were treated during that period, but only 82 cases diagnosed by FNAC could be correlated with histological and clinical data and were considered for this study. The sensitivity, specificity, diagnostic accuracy, PPV and NPV were estimated considering 54 benign and 28 malignant cases. Sensitivity was 90% (28/31), specificity was 98% (54/55), diagnostic accuracy was 95.1% (82/86), PPV was 96% and NPV was 94%.
This study confirms that FNA cytology is a technique that offers high sensitivity, specificity and diagnostic accuracy in salivary gland tumour diagnosis.
本研究的目的是评估在一家三级癌症医院进行的为期10年的唾液腺肿瘤细针穿刺细胞学检查（FNAC）的敏感性、特异性、诊断准确性、阳性预测值（PPV）和阴性预测值（NPV）。
对1995年至2004年间的病例进行回顾性分析，以审查接受术前FNA检查且通过粗针活检或手术标本的组织病理学检查获得明确组织学诊断的唾液腺肿瘤患者的病例。
在此期间共治疗了107例唾液腺肿瘤病例，但只有82例经FNAC诊断的病例能够与组织学和临床数据相关联，并纳入本研究。考虑54例良性病例和28例恶性病例，对敏感性、特异性、诊断准确性、PPV和NPV进行了评估。敏感性为90%（28/31），特异性为98%（54/55），诊断准确性为95.1%（82/86），PPV为96%，NPV为94%。
本研究证实，FNA细胞学检查是一种在唾液腺肿瘤诊断中具有高敏感性、特异性和诊断准确性的技术。
