Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Antimicrob Agents Chemother. 2011 Nov;55(11):5374-5. doi: 10.1128/AAC.05437-11. Epub 2011 Sep 6.
A low rate of resistance (0.24%) to rifabutin was noted in Helicobacter pylori strains isolated from 414 Japanese patients. The only rifabutin-resistant strain detected showed a point mutation in the rpoB gene and was isolated from a patient with a history of rifampin treatment for pulmonary tuberculosis.
从 414 例日本患者中分离的幽门螺杆菌菌株对利福布汀的耐药率较低(0.24%)。唯一检测到的耐利福布汀菌株显示 rpoB 基因突变,该菌株从一名曾因肺结核接受利福平治疗的患者中分离。