Intraocular pressure and associated factors: the central India eye and medical study.

PURPOSE

To determine the range of intraocular pressure (IOP) in a rural Central Indian population and to evaluate existing and identify potential new ocular, medical, and socioeconomic factors associated with IOP.

METHODS

This is a population-based study carried out in Nagpur in Central India. A single IOP measurement was taken using Goldmann applanation tonometry and population IOP was described using standard descriptive statistics.

RESULTS

Of 5885 eligible patients, 9338 eyes of 4686 patients were included in the study. The mean IOP was 13.6±3.4 mm Hg (median: 14 mm Hg; range: 2 to 56 mm Hg). In multivariate regression analysis, the following factors, with correlation coefficients (r) and P values reported in parenthesis, were found to be associated with IOP. Ocular factors included higher corneal power (0.12; P=0.004), lower central corneal thickness (0.02; P<0.001), and higher myopic refractive power (-0.13; P=0.001). Medical factors included diastolic blood pressure (0.05; P<0.001), pulse rate (0.02; P=0.005), and body mass index (0.05; P=0.01). Socioeconomic factors included level of education (0.15; P=0.05) and livestock ownership (-0.18; P=0.008).

CONCLUSION

Low mean IOP was found when compared with other epidemiologic studies and this may be explained by the low central corneal thickness found in the study population. Several known ocular and medical factors and new socioeconomic factors were found to be associated with IOP. Identifying risk factors associated with IOP in different populations may allow clinicians to better define and recognize subgroups of patients at risk of elevated IOP. Newly identified socioeconomic-IOP associations will need to be validated in future studies.