儿童注意缺陷多动障碍与亚甲基四氢叶酸还原酶基因多态性的相关性研究
Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder.
机构信息
Department of Child and Adolescent Psychiatry, Medicine Faculty of Gaziantep University, Gaziantep, Turkey.
出版信息
Int J Med Sci. 2011;8(7):523-8. doi: 10.7150/ijms.8.523. Epub 2011 Aug 30.
Abstract
OBJECTIVE
The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children.
STUDY DESIGN
MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms.
RESULTS
Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033).
CONCLUSIONS
Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.
摘要
目的
本研究旨在评估 5,10-亚甲基四氢叶酸还原酶 (MTHFR) 多态性与土耳其儿童注意缺陷多动障碍 (ADHD) 之间的关系。
研究设计
在 40 名 ADHD 患者和 30 名健康对照组中评估 MTHFR 基因突变。使用聚合酶链反应和限制性片段长度多态性检测 MTHFR 基因的两个突变。
结果
尽管 ADHD 组和对照组之间 C677T 等位基因的基因型分布无统计学差异（p=0,678），但 ADHD 患者和对照组之间 A1298C 等位基因的基因型分布模式不同（p=0,033）。
结论
初步数据表明，MTHFR A1298C 多态性与 ADHD 之间可能存在关联。
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