对双木脂醌 A 的对映选择性全合成及构象稳定性研究。
Enantioselective total synthesis and studies into the configurational stability of bismurrayaquinone A.
机构信息
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9931-4. doi: 10.1002/anie.201104726. Epub 2011 Sep 7.
Abstract
Lost in rotation: the concise strategy of the first enantioselective total synthesis of bismurrayaquinone A utilized traceless stereochemical exchange to form an enantioenriched biphenyl core that was elaborated in a bidirectional manner to the natural product. Observed racemization on an unsuccessful initial route prompted studies into the configurational stability of bismurrayaquinone A and related biquinones.
摘要
迷失在旋转中
首次对双木脂素 A 的对映选择性全合成采用简洁的策略，利用无痕迹的立体化学交换形成手性富集的联苯核心，然后以双向方式对天然产物进行修饰。在最初的不成功路线上观察到的外消旋化促使对双木脂素 A 和相关的倍半木脂素的构型稳定性进行研究。
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