关于螺旋曲霉三烯酮A核心骨架合成的研究。
Studies toward synthesis of the core skeleton of spiroaspertrione A.
作者信息
Shen Zhong-Hui, Lu Si-Yuan, Zheng Jing-Yun, Zhang Xiang-Zhi, Peng Jin-Bao, Ma Ai-Jun
机构信息
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
出版信息
Front Chem. 2022 Oct 5;10:1022533. doi: 10.3389/fchem.2022.1022533. eCollection 2022.
Bioassay-guided isolation of spiroaspertrione A from cultures of . TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1'-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.
2017年从TJ23培养物中通过生物测定引导分离出螺旋曲霉三酮A，它通过将苯唑西林的最低抑菌浓度降低至32倍，证明了苯唑西林对耐甲氧西林菌具有有效的再敏化作用。为构建这种独特的螺[双环[3.2.2]壬烷-2,1'-环己烷]体系，公开了一种硝酸铈铵诱导的硅烯醇盐分子内交叉偶联的方法。
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