Gorgun Ebru, Yenerel Nursal Melda, Dinc Umut Asli, Oncel Banu, Kucumen Raciha Beril, Oral Deniz, Ciftci Ferda
Yeditepe University, Faculty of Medicine, Department of Ophthalmology, Istanbul, Turkey.
Ophthalmic Surg Lasers Imaging. 2011 Sep-Oct;42(5):400-7. doi: 10.3928/15428877-20110812-02.
This study examined the repeatability of and agreements between central corneal thickness measurements obtained by four different non-contact pachymetry devices.
Seventy-eight eyes of 39 subjects were included. Central corneal thickness of each eye was measured by Visante optical coherence tomography (OCT) (Carl Zeiss Meditec Inc., Dublin, CA), Pentacam (Oculus Optikgeräte GmbH, Wetzlar, Germany), Orbscan IIz topography (Bausch & Lomb Surgical Inc., San Dimas, CA), and slit-lamp OCT (SL-OCT) (Heidelberg Engineering GmbH, Heidelberg, Germany). Inter-device agreements and correlations and repeatability of each device were examined.
All measurement methods correlated well with each other with a correlation coefficient greater than 0.90 and P value of less than .001 for all comparisons. However, Pentacam overestimated central corneal thickness: 546.7 ± 38.2, 535.5 ± 42.7, 531.7 ± 37.6, and 531.2 ± 36.0 μm for Pentacam, Orbscan IIz, Visante OCT, and SL-OCT, respectively (P < .001 for all comparisons versus Pentacam). Despite good correlation, magnitude of differences was high and this bias was proportional (ie, not constant across a range of corneal thickness values) for the following pairs: Orbscan versus Visante OCT, Orbscan versus SL-OCT, and Orbscan versus Pentacam (P < .001 for all comparisons).
Although measurements obtained by various non-contact methods correlate well, numerical agreement of the results may not be sufficient for their interchangeable use in clinical practice.
本研究检测了四种不同非接触式角膜测厚仪所测中央角膜厚度的可重复性及一致性。
纳入39名受试者的78只眼。使用Visante光学相干断层扫描（OCT）（卡尔·蔡司医疗技术公司，加利福尼亚州都柏林）、Pentacam（奥culus光学仪器有限公司，德国韦茨拉尔）、Orbscan IIz地形图仪（博士伦外科公司，加利福尼亚州圣迪马斯）和裂隙灯OCT（SL - OCT）（海德堡工程有限公司，德国海德堡）测量每只眼的中央角膜厚度。检测了不同仪器间的一致性、相关性及各仪器的可重复性。
所有测量方法之间相关性良好，所有比较的相关系数均大于0.90，P值均小于0.001。然而，Pentacam高估了中央角膜厚度：Pentacam、Orbscan IIz、Visante OCT和SL - OCT所测厚度分别为546.7±38.2、535.5±42.7、531.7±37.6和531.2±36.0μm（与Pentacam相比，所有比较的P均<0.001）。尽管相关性良好，但差异幅度较大，且对于以下几组仪器，这种偏差是成比例的（即在一系列角膜厚度值范围内并非恒定）：Orbscan与Visante OCT、Orbscan与SL - OCT以及Orbscan与Pentacam（所有比较的P均<0.001）。
尽管各种非接触式方法所测结果相关性良好，但结果的数值一致性可能不足以使其在临床实践中可互换使用。
