新生儿循环单核细胞中生长调节素受体位点增加。

Increased somatomedin receptor sites in newborn circulating mononuclear cells.

作者信息

Rosenfeld R, Thorsson A V, Hintz R L

出版信息

J Clin Endocrinol Metab. 1979 Mar;48(3):456-61. doi: 10.1210/jcem-48-3-456.

Abstract

To evaluate the potential role of somatomedin as a growth factor in fetal development, we studied somatomedin receptors on circulating mononuclear cells from placental cord blood from 13 normal term newborns. Twelve healthy young adults served as controls. By radioreceptor assay of acid-chromatographed plasma, total somatomedin peptide content of cord blood was 0.30 +/- 0.02 U/ml (mean +/- SEM) compared to 1.12 +/- 0.08 U/ml for adults. Specific binding of [125I]somatomedin C to 50 X 10(6) mononuclear cells was 11.38 +/- 0.74% for newborns and 6.67 +/- 0.51% for adults. This increase in specific binding appears to be due to an increased number of receptor sites per cell. These data support a hypothesis of increased fetal sensitivity to somatomedin.

摘要

为了评估生长调节素作为一种生长因子在胎儿发育中的潜在作用，我们研究了来自13名足月正常新生儿胎盘脐带血中循环单核细胞上的生长调节素受体。12名健康的年轻成年人作为对照。通过对酸层析血浆的放射受体测定，脐带血中生长调节素肽的总含量为0.30±0.02 U/ml（平均值±标准误），而成人则为1.12±0.08 U/ml。[125I]生长调节素C与50×10(6)个单核细胞的特异性结合，新生儿为11.38±0.74%，成人为6.67±0.51%。这种特异性结合的增加似乎是由于每个细胞上受体位点数量的增加。这些数据支持了胎儿对生长调节素敏感性增加的假说。