Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Phytomedicine. 2012 Feb 15;19(3-4):369-73. doi: 10.1016/j.phymed.2011.08.061. Epub 2011 Sep 6.
Ginsenoside-Rd (GS-Rd) is one of the major active components of Panax ginseng, and was shown to have the protective effects against several insults. However, we still lack some basic knowledge of GS-Rd, including its pharmacokinetic, tissue distribution and excretion in vivo in experimental animal, such as mice and rats. In this study, HPLC and radioactive tracer assays were performed to determine pharmacokinetic, tissue distribution and excretion of GS-Rd in rodents. After intravascular administration with 20, 50 or 150 mg/kg GS-Rd, the dynamic changes of GS-Rd concentrations in plasma were consistent with a two-compartment model while the concentration of ³H-labeled GS-Rd was rapidly reached the peak in plasma, and distributed to various tissues, among which the highest concentration was observed in the lung.
人参皂苷-Rd（GS-Rd）是人参的主要活性成分之一，具有多种保护作用。然而，我们对其药代动力学、组织分布和体内排泄等基本特性仍缺乏了解，包括在实验动物（如小鼠和大鼠）中的药代动力学、组织分布和排泄。本研究采用 HPLC 和放射性示踪剂分析方法，研究了 GS-Rd 在啮齿类动物中的药代动力学、组织分布和排泄。静脉给予 20、50 或 150mg/kgGS-Rd 后，GS-Rd 浓度在血浆中的动态变化符合二室模型，而放射性标记的 GS-Rd 浓度则迅速在血浆中达到峰值，并分布到各种组织中，其中肺中浓度最高。
