Li Jing, Huang Qingxia, Yao Yao, Ji Peng, Mingyao E, Chen Jinjin, Zhang Zepeng, Qi Hongyu, Liu Jiaqi, Chen Zhaoqiang, Zhao Daqing, Zhou Lei, Li Xiangyan
Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Research Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Front Pharmacol. 2022 Jul 19;13:909363. doi: 10.3389/fphar.2022.909363. eCollection 2022.
C.A. Mey. has a history of more than 4000 years and is widely used in Asian countries. Modern pharmacological studies have proved that ginsenosides and their compounds have a variety of significant biological activities on specific diseases, including neurodegenerative diseases, certain types of cancer, gastrointestinal disease, and metabolic diseases, in which most of the interest has focused on ginsenoside Rd. The evidentiary basis showed that ginsenoside Rd ameliorates ischemic stroke, nerve injury, cancer, and other diseases involved in apoptosis, inflammation, oxidative stress, mitochondrial damage, and autophagy. In this review, we summarized available reports on the molecular biological mechanisms of ginsenoside Rd in neurological diseases, cancer, metabolic diseases, and other diseases. We also discussed the main biotransformation pathways of ginsenoside Rd obtained by fermentation.
刺五加有着4000多年的历史，在亚洲国家被广泛使用。现代药理学研究证明，人参皂苷及其化合物对特定疾病具有多种显著的生物活性，包括神经退行性疾病、某些类型的癌症、胃肠道疾病和代谢疾病，其中大部分研究兴趣集中在人参皂苷Rd上。证据表明，人参皂苷Rd可改善缺血性中风、神经损伤、癌症以及其他涉及细胞凋亡、炎症、氧化应激、线粒体损伤和自噬的疾病。在这篇综述中，我们总结了关于人参皂苷Rd在神经疾病、癌症、代谢疾病和其他疾病中分子生物学机制的现有报道。我们还讨论了通过发酵获得的人参皂苷Rd的主要生物转化途径。
