意大利产 KPC-3 型肺炎克雷伯菌爆发的控制。
Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy.
机构信息
Department GF Ingrassia, University of Catania, Catania, Italy.
出版信息
J Clin Microbiol. 2011 Nov;49(11):3986-9. doi: 10.1128/JCM.01242-11. Epub 2011 Sep 7.
Abstract
From March 2009 to May 2009, 24 carbapenem-resistant Klebsiella pneumoniae isolates were recovered from 16 patients hospitalized in an Italian intensive care unit (ICU). All isolates contained KPC-3 carbapenemase and belonged to a single pulsed-field gel electrophoresis (PFGE) clone of multilocus sequence type 258 (designated as ST258). A multimodal infection control program was put into effect, and the spread of the KPC-3-producing K. pneumoniae clone was ultimately controlled without closing the ICU to new admissions. Reinforced infection control measures and strict monitoring of the staff adherence were necessary for the control of the outbreak.
摘要
从 2009 年 3 月到 2009 年 5 月，意大利重症监护病房（ICU）的 16 名住院患者中分离出 24 株耐碳青霉烯类肺炎克雷伯菌。所有分离株均含有 KPC-3 碳青霉烯酶，且属于同一脉冲场凝胶电泳（PFGE）多位点序列型 258（命名为 ST258）克隆。实施了多模式感染控制方案，最终在不关闭 ICU 收治新患者的情况下控制了产 KPC-3 肺炎克雷伯菌克隆的传播。强化感染控制措施和严格监测工作人员的遵守情况对于控制疫情是必要的。
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