Thandavarayan Rajarajan A, Giridharan Vijayasree V, Watanabe Kenichi, Konishi Tetsuya
Department of Functional and Analytical Food Sciences, Niigata University of Pharmacy and Applied Life Sciences NUPALS, Higashijima 265-1 Akiha-Ku, Niigata, 956-8603, Japan.
Cardiovasc Hematol Agents Med Chem. 2011 Oct;9(4):225-30. doi: 10.2174/187152511798120877.
Diabetes has emerged as a major threat to worldwide health. The increasing incidence of diabetes in young individuals is particularly worrisome given that the disease is likely to evolve over a period of years. In 1972, the existence of a diabetic cardiomyopathy was proposed based on the experience with four adult diabetic patients who suffered from congestive heart failure in the absence of discernible coronary artery disease, valvular or congenital heart disease, hypertension, or alcoholism. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemiainduced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. In this review, we provide the emergence of experimental evidence supporting antioxidant supplementation as a cardioprotective intervention in the setting of diabetic cardiomyopathy.
糖尿病已成为全球健康的重大威胁。鉴于糖尿病可能在数年内发展，其在年轻人中的发病率不断上升尤其令人担忧。1972年，基于4名成年糖尿病患者的经验提出了糖尿病性心肌病的存在，这些患者在没有明显冠状动脉疾病、瓣膜或先天性心脏病、高血压或酗酒的情况下患有充血性心力衰竭。该疾病的确切机制尚不清楚；然而，越来越多的证据表明，主要由于高血糖导致的高反应性自由基的过量产生会引起氧化应激，这进一步加剧了糖尿病及其并发症的发生和发展。高血糖诱导的氧化应激是糖尿病心肌微血管病变发生发展的主要危险因素，可导致心肌细胞死亡、肥大、纤维化、钙稳态异常和内皮功能障碍。在这篇综述中，我们提供了实验证据的出现，支持补充抗氧化剂作为糖尿病性心肌病的心脏保护干预措施。
