Fyhrquist F, Saijonmaa O, Metsärinne K, Tikkanen I, Rosenlöf K, Tikkanen T
Unit of Clinical Physiology, Minerva Institute for Medical Research, Helsinki, Finland.
Biochem Biophys Res Commun. 1990 May 31;169(1):217-21. doi: 10.1016/0006-291x(90)91456-3.
Plasma concentration of immunoreactive endothelin-1 was measured by radioimmunoassay in 6 healthy subjects before and following cold pressor test by immersion of one fore-arm into ice-water. Mean (SEM) plasma endothelin-1 concentration rose from 1.2 (0.7) to peak value 8.4 (2.3) pg/ml in venous plasma from the immersed hand, and, reaching peak 2 minutes later, from 1.4 (0.5) to 4.6 (2.3) pg/ml in venous plasma from the contralateral hand. In 66 healthy control subjects, venous plasma concentration of endothelin-1 was 2.9 +/- 1.2 pg/ml (mean +/- SD). Exposure to cold is associated with raised blood levels of endothelin-1, which points to a relation between endothelin-1 and vasoconstriction associated with low temperature.
通过放射免疫分析法，在6名健康受试者将一侧前臂浸入冰水中进行冷加压试验之前和之后，测量了免疫反应性内皮素-1的血浆浓度。浸入侧手部静脉血浆中，平均（标准误）血浆内皮素-1浓度从1.2（0.7）皮克/毫升升至峰值8.4（2.3）皮克/毫升，对侧手部静脉血浆中浓度在2分钟后达到峰值，从1.4（0.5）皮克/毫升升至4.6（2.3）皮克/毫升。在66名健康对照受试者中，内皮素-1的静脉血浆浓度为2.9±1.2皮克/毫升（平均值±标准差）。暴露于寒冷环境与内皮素-1血液水平升高有关，这表明内皮素-1与低温相关的血管收缩之间存在关联。
