Department of Anesthesiology and Critical Care and SAMU, Lariboisière Hospital, Assistance Publique- Hopitaux de Paris; University of Paris 7 Denis Diderot, 2 rue Ambroise-Paré, 75475 Paris Cedex 10, France.
Ann Intensive Care. 2011 May 24;1(1):13. doi: 10.1186/2110-5820-1-13.
Urine output often is used as a marker of acute kidney injury but also to guide fluid resuscitation in critically ill patients. Although decrease of urine output may be associated to a decrease of glomerular filtration rate due to decrease of renal blood flow or renal perfusion pressure, neurohormonal factors and functional changes may influence diuresis and natriuresis in critically ill patients. The purpose of this review is to discuss the mechanisms of diuresis regulation, which may help to interpret the urine output in critically ill patients and the appropriate treatment to be initiated in case of changes in urine output.
尿液输出量通常被用作急性肾损伤的标志物，也可用于指导危重症患者的液体复苏。虽然由于肾血流量或肾灌注压降低导致肾小球滤过率降低，可能会出现尿液输出量减少，但神经激素因素和功能变化可能会影响危重症患者的利尿和排钠作用。本文的目的是讨论利尿调节的机制，这有助于解释危重症患者的尿液输出量，并在尿液输出量发生变化时确定适当的治疗方案。
