Ellenberg J H
Biometry and Field Studies Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
Biometrics. 1990 Mar;46(1):1-18; discussion 19-32.
There has been an explosive growth in the development of statistical methodology over the past several decades. Research in both medicine and public health, in which the involvement of biostatisticians has increased dramatically during this period, has been both a beneficiary of this new methodology as well as a source of new problems. The contributions of statistical methodology in design, implementation, and analysis as they relate to the role that biostatistics and biostatisticians now play in the field of medical research are addressed. We comment on: (1) the acceptance by the medical community that biostatistical concepts are an integral part of sound medical research; (2) the sometimes unrealistic expectations placed on biostatistics and biostatisticians given limited resources and/or limited control; (3) some controversies among biostatisticians; and (4) the need for emphasizing the design and implementation phases of medical investigations.
在过去几十年中，统计方法学的发展呈爆炸式增长。医学和公共卫生领域的研究在此期间受益于这种新方法学，同时也产生了新问题，在此期间生物统计学家的参与度大幅增加。本文阐述了统计方法学在设计、实施和分析方面的贡献，以及它们与生物统计学和生物统计学家目前在医学研究领域所发挥的作用之间的关系。我们评论了以下几点：（1）医学界认可生物统计学概念是合理医学研究不可或缺一部分；（2）在资源有限和/或控制有限的情况下，有时对生物统计学和生物统计学家抱有不切实际的期望；（3）生物统计学家之间存在的一些争议；（4）强调医学研究设计和实施阶段的必要性。
