气相中肽键的可控形成。
Controlled formation of peptide bonds in the gas phase.
机构信息
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
出版信息
J Am Chem Soc. 2011 Oct 12;133(40):15834-7. doi: 10.1021/ja205471n. Epub 2011 Sep 16.
Abstract
Photoexcitation (using 157 nm vacuum ultraviolet radiation) of proton-bound peptide complexes leads to water elimination and the formation of longer amino acid chains. Thus, it appears that proton-bound dimers are long-lived intermediates along the pathway to peptide formation. Product specificity can be controlled by selection of specific complexes and the incorporation of blocking groups at the N- or C-termini. The product peptide sequences are confirmed using collision-induced dissociation.
摘要
光解（使用 157nm 真空紫外辐射）质子束缚肽复合物导致水的消除和更长的氨基酸链的形成。因此，质子束缚二聚体似乎是形成肽的途径中的长寿命中间体。通过选择特定的复合物和在 N 端或 C 端引入封闭基团，可以控制产物的特异性。使用碰撞诱导解离来确认产物肽序列。
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