Crebelli R, Aquilina G, Conti L, Carere A
Istituto Superiore di Sanità, Rome, Italy.
Microbiologica. 1990 Apr;13(2):115-9.
Sixty-five commercial samples of natural flavouring substances were screened for mutagenicity in the Salmonella typhimurium strains TA98 and TA100. The results obtained demonstrated a significant mutagenic activity in onion and garlic extracts, both in assays with and without exogenous metabolic activation. The response pattern obtained in tester strains with different genetic backgrounds suggests the involvement of mutagenic flavone(s) in the genotoxic effects observed.
对65份天然调味物质的商业样品进行了鼠伤寒沙门氏菌TA98和TA100菌株的致突变性筛查。所获结果表明，洋葱和大蒜提取物在有无外源性代谢活化的试验中均具有显著的诱变活性。在具有不同遗传背景的测试菌株中获得的反应模式表明，诱变黄酮参与了所观察到的遗传毒性效应。
