Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
J Am Chem Soc. 2011 Nov 16;133(45):18183-93. doi: 10.1021/ja203978r. Epub 2011 Oct 21.
A ligand-accelerated Pd(II)-catalyzed C(sp(2))-H/arylboron cross-coupling reaction of phenylacetic acid substrates is reported. Using Ac-Ile-OH as the ligand and Ag(2)CO(3) as the oxidant, a fast, high-yielding, operationally simple, and functional group-tolerant protocol has been developed for the cross-coupling of phenylacetic acid substrates with aryltrifluoroborates. This ligand scaffold has also been shown to improve catalysis using 1 atm O(2) as the sole reoxidant, which sheds light on the path forward in developing optimized ligands for aerobic C-H/arylboron cross-coupling.
报道了一种配体加速的 Pd(II)催化的 C(sp(2))-H/芳基硼酸交叉偶联反应，涉及苯乙酸底物。使用 Ac-Ile-OH 作为配体和 Ag(2)CO(3)作为氧化剂，开发了一种快速、高产、操作简单且官能团容忍的苯乙酸底物与芳基三氟硼酸盐交叉偶联的方法。该配体支架还被证明可以改善使用 1 atm O(2)作为唯一氧化剂的催化作用，为开发有氧 C-H/芳基硼酸交叉偶联的优化配体指明了方向。
