Ding Wen-wei, Tian Ying, Jin Jun, Wang Ying, Cui Chang, Zhang Lin, Gao Yu, Wang Xiao-jin, Shi Rong
College of Life and Environment Science, Minzu University of China, Beijing 100081, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jun;45(6):498-501.
To explore the level of hexabromocyclododecane (HBCD) in human breast milk of delivery women in a Shanghai hospital, and estimate the daily intake of newborns from breast milk.
Forty-eight delivery women in a Shanghai suburb hospital (Class A, Grade 3) were surveyed by questionnaires, and their breast milk samples were collected from September 2006 to April 2007. All the delivery women were singleton pregnancies, excluding high blood pressure, diabetes, HIV infection and adverse medical history. Three diastereoisomers (α-HBCD, β-HBCD, γ-HBCD) were measured by the liquid chromatography-electrospray ion source-tandem mass spectrometry, and then estimated the daily intake of the newborns from the breast milk.
The total HBCD concentration of breast milk, which was detected in 79% (38/48) of samples, ranged from 0.11 ng/g lipid weight (lw) to 37.75 ng/g lw, with the median at 1.42 ng/g lw. The most abundant diastereoisomer was α-HBCD which detected in 77% (37/48) of samples, with a median of 1.24 ng/g lw; followed by γ-HBCD and β-HBCD, detected in 13% (6/48) and 17% (8/48) of samples respectively, whose median were both under the limit of detection (LOD). The daily intake of the newborns from the breast milk ranged from 0.71 ng/kg to 243.46 ng/kg.
The concentrations of HBCD in breast milk of delivery women in a Shanghai hospital have been in a high level, and the influence on newborns' health need to be further studied.
探究上海某医院分娩女性母乳中六溴环十二烷（HBCD）的含量水平，并估算新生儿通过母乳的每日摄入量。
对上海一家郊区三级甲等医院的48名分娩女性进行问卷调查，并于2006年9月至2007年4月采集她们的母乳样本。所有分娩女性均为单胎妊娠，排除患有高血压、糖尿病、艾滋病毒感染及不良病史者。采用液相色谱 - 电喷雾离子源 - 串联质谱法测定三种非对映异构体（α - HBCD、β - HBCD、γ - HBCD），进而估算新生儿通过母乳的每日摄入量。
在79%（38/48）的样本中检测到母乳中HBCD的总浓度，范围为0.11纳克/克脂质重量（lw）至37.75纳克/克lw，中位数为1.42纳克/克lw。含量最丰富的非对映异构体是α - HBCD，在77%（37/48）的样本中检测到，中位数为1.24纳克/克lw；其次是γ - HBCD和β - HBCD，分别在13%（6/48）和17%（8/48）的样本中检测到，它们的中位数均低于检测限（LOD）。新生儿通过母乳的每日摄入量范围为0.71纳克/千克至243.46纳克/千克。
上海某医院分娩女性母乳中HBCD的浓度处于较高水平，其对新生儿健康的影响有待进一步研究。
