University of Rome-La Sapienza, Department of Neurology and Psychiatry, Viale Università 30, 00185 Rome, Italy.
Expert Opin Pharmacother. 2011 Oct;12(15):2355-68. doi: 10.1517/14656566.2011.607162.
Multiple sclerosis (MS) is an inflammatory, demyelinating, central nervous system disease that frequently causes pain.
This article reviews the current literature and describes the therapeutic options for treating MS-related pain. The reader will be provided with current, evidence-based knowledge about the treatment of MS-related pain, and the review will take a practical approach to the various drugs for treating pain, including starting dose, titration and side effects.
Only cannabinoids have been assessed in randomized, controlled trials. Because of the concern regarding the risk of abuse and psychiatric adverse events, published guidelines as well as expert recommendations suggest using them as second-line therapy only. Hence, current treatment should be based on the general principles for treating peripheral neuropathic pain, taking into account drug-induced adverse effects.
多发性硬化症（MS）是一种炎症性、脱髓鞘性中枢神经系统疾病，常引起疼痛。
本文综述了目前的文献，并描述了治疗 MS 相关疼痛的治疗选择。读者将获得有关治疗 MS 相关疼痛的最新循证医学知识，并且该综述将采用实用的方法来介绍各种治疗疼痛的药物，包括起始剂量、滴定和副作用。
只有大麻素在随机对照试验中进行了评估。由于对滥用和精神不良事件的风险的担忧，已发布的指南和专家建议建议仅将其作为二线治疗。因此，目前的治疗应基于治疗周围神经性疼痛的一般原则，同时考虑药物引起的不良反应。
