Sotelo J, del Brutto O H, Penagos P, Escobedo F, Torres B, Rodriguez-Carbajal J, Rubio-Donnadieu F
National Institute of Neurology and Neurosurgery of Mexico.
J Neurol. 1990 Apr;237(2):69-72. doi: 10.1007/BF00314663.
The efficacy of different regimens of therapy for parenchymal brain cysticercosis either with praziquantel (PZQ) or with albendazole (ALB) was compared in 114 patients. Four schemes of treatment were used: PZQ 50 mg/kg per day for 15 days, PZQ 50 mg/kg per day for 8 days, ALB 15 mg/kg per day for 30 days, and ALB 15 mg/kg per day for 8 days. Three months after therapy, it was apparent that both PZQ and ALB were effective, as shown by the disappearance of cystic lesions in computed tomographic scans. Thirty-three control patients followed for a mean of 11 months had no spontaneous remission of lesions. When comparing PZQ with ALB, the latter was found to be more effective than the former for both the full and the short course of treatment: 85% vs 60% and 85% vs 48% disappearance of lesions, respectively (P less than 0.001). Comparison of the full vs the short course of PZQ showed that the short course had a further 12% reduction in drug effectiveness. In contrast, the length of ALB therapy could be shortened without lessening its efficacy. Based on these results, an 8-day course of ALB is recommended as treatment for parenchymal brain cysticercosis; a 15-day course of PZQ could be subsequently used in those patients who show only partial response to ALB.
对114例脑实质型囊尾蚴病患者比较了使用吡喹酮（PZQ）或阿苯达唑（ALB）的不同治疗方案的疗效。采用了四种治疗方案：PZQ每日50mg/kg，共15天；PZQ每日50mg/kg，共8天；ALB每日15mg/kg，共30天；ALB每日15mg/kg，共8天。治疗三个月后，计算机断层扫描显示囊性病变消失，表明PZQ和ALB均有效。33例对照患者平均随访11个月，病变无自发缓解。比较PZQ和ALB时，发现后者在全疗程和短疗程治疗中均比前者更有效：病变消失率分别为85%对60%和85%对48%（P<0.001）。比较PZQ的全疗程和短疗程发现，短疗程的药物有效性进一步降低了12%。相反，ALB治疗疗程可以缩短而不降低其疗效。基于这些结果，推荐8天疗程的ALB作为脑实质型囊尾蚴病的治疗方法；对于那些对ALB仅部分反应的患者，随后可使用15天疗程的PZQ。
