Sotelo J, Penagos P, Escobedo F, Del Brutto O H
Instituto Nacional de Neurologia-y Neurocirugia, Mexico City, DF.
Arch Neurol. 1988 Oct;45(10):1130-3. doi: 10.1001/archneur.1988.00520340084017.
Albendazole is now used for therapy of neurocysticercosis; however, duration of treatment has usually been empirically determined. In this study we shortened the length of therapy from one month in previous reports, to one week. Twelve patients with parenchymal brain cysticercosis were treated with albendazole for eight days at daily doses of 15 mg/kg of body weight. After three months of treatment the number of cysts on computed tomography had decreased from 185 to six; a 97% reduction in the number of lesions. Total remission of all cysts was seen in nine patients. Two cases had been unsuccessfully treated before with praziquantel, in both instances albendazole therapy was effective with 100% improvement. Our results indicated that a short course of albendazole is highly effective for treatment of neurocysticercosis.
阿苯达唑目前用于治疗神经囊尾蚴病；然而，治疗疗程通常是凭经验确定的。在本研究中，我们将治疗疗程从先前报告中的一个月缩短至一周。12例脑实质囊尾蚴病患者接受阿苯达唑治疗，每日剂量为15mg/kg体重，共8天。治疗三个月后，计算机断层扫描显示囊肿数量从185个减少至6个；病变数量减少了97%。9例患者的所有囊肿完全消退。2例患者之前使用吡喹酮治疗失败，而使用阿苯达唑治疗均有效，改善率达100%。我们的结果表明，短疗程阿苯达唑治疗神经囊尾蚴病非常有效。
