Zoology Institute, Department of Zoo-Physiology, Christian-Albrechts University, Kiel, Germany.
Hum Immunol. 2011 Dec;72(12):1188-93. doi: 10.1016/j.humimm.2011.08.015. Epub 2011 Aug 28.
There is a permanent interaction amid the innate and adaptive immune systems that leads to a defensive immune response against pathogens and contributes substantially to self-nonself discrimination. Toll-like receptors (TLRs) are essential molecules of the innate immune system that stimulate numerous inflammatory pathways and harmonize systemic defense against a wide array of pathogens. In addition to identifying unique molecular patterns associated with various sections of pathogens, TLRs may also recognize a number of self proteins and endogenous nucleic acids. Several reports have indicated that inappropriate stimulation of the TLR pathway via endogenous or exogenous ligands in animal models or humans may lead to the induction and/or prolongation of autoimmune response and tissue injury.
固有免疫和适应性免疫系统之间存在着一种永久性的相互作用，这种相互作用导致了针对病原体的防御性免疫反应，并在很大程度上有助于自我-非我识别。 Toll 样受体 (TLR) 是固有免疫系统的重要分子，它可刺激多种炎症途径，并协调全身性防御以抵抗各种病原体。除了识别与病原体不同部分相关的独特分子模式外，TLR 还可以识别许多自身蛋白和内源性核酸。一些报道表明，在动物模型或人类中，内源性或外源性配体对 TLR 途径的不适当刺激可能导致自身免疫反应和组织损伤的诱导和/或延长。
