天然产物对固有免疫中Toll样受体信号传导的调节作用。
Modulation of Toll-like receptor signaling in innate immunity by natural products.
作者信息
Chen Luxi, Yu Jianhua
机构信息
Medical Scientist Training Program, The Ohio State University, Columbus, OH, USA.
Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital & Solove Research Center, Columbus, OH, USA.
出版信息
Int Immunopharmacol. 2016 Aug;37:65-70. doi: 10.1016/j.intimp.2016.02.005. Epub 2016 Feb 15.
Abstract
For centuries, natural products and their derivatives have provided a rich source of compounds for the development of new immunotherapies in the treatment of human disease. Many of these compounds are currently undergoing clinical trials, particularly as anti-oxidative, anti-microbial, and anti-cancer agents. However, the function and mechanism of natural products in how they interact with our immune system has yet to be extensively explored. Natural immune modulators may provide the key to control and ultimately defeat disorders affecting the immune system. They can either up- or down-regulate the immune response with few undesired adverse effects. In this review, we summarize the recent advancements made in utilizing natural products for immunomodulation and their important molecular targets, members of the Toll-like receptor (TLR) family, in the innate immune system.
摘要
几个世纪以来，天然产物及其衍生物为开发治疗人类疾病的新型免疫疗法提供了丰富的化合物来源。目前，这些化合物中有许多正在进行临床试验，特别是作为抗氧化剂、抗菌剂和抗癌剂。然而，天然产物与我们免疫系统相互作用的功能和机制尚未得到广泛探索。天然免疫调节剂可能是控制并最终战胜影响免疫系统疾病的关键。它们可以上调或下调免疫反应，且几乎没有不良副作用。在本综述中，我们总结了利用天然产物进行免疫调节的最新进展及其在固有免疫系统中的重要分子靶点——Toll样受体（TLR）家族成员。
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