Department of Clinical Epidemiology, School of Public Health, Aarhus University, Aarhus University Hospital, Aalborg, Denmark.
Obes Facts. 2011;4(4):312-8. doi: 10.1159/000330710. Epub 2011 Aug 1.
We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.
A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression.
The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different.
The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
我们研究了在入组时采集的血液样本中血浆磷脂长链 n-3 多不饱和脂肪酸（PUFA）的比例与随后体重变化之间的关系。性别、年龄和 BMI 被认为是潜在的效应修饰剂。
共有 1998 名参加欧洲癌症前瞻性调查和营养研究（EPIC）的女性和男性参与者，随访中位数为 4.9 年。使用混合效应线性回归研究了血浆磷脂长链 n-3 PUFA 比例与体重变化之间的关系。
长链 n-3 PUFA 的比例与体重变化无关。在所有参与者中，长链 n-3 PUFA 水平每增加 1%，1 年内体重变化为-0.7 克（95%置信区间：-20.7 至 19.3）。按性别、年龄或 BMI 组分层的结果没有系统差异。
本研究结果表明，在一般人群的暴露范围内，血浆磷脂中长链 n-3 PUFA 的比例与随后的体重变化无关。
