Department of Ophthalmology, Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, Quebec, Canada.
Eye (Lond). 2011 Dec;25(12):1590-7. doi: 10.1038/eye.2011.217. Epub 2011 Sep 16.
To describe different methods of inter-eye asymmetry of rim area (RA) to disc area (DA) asymmetry ratio (RADAAR) analysis.
This was an observational, descriptive, and cross-sectional study. Both the eyes of all participants underwent confocal scanning laser ophthalmoscopy (Heidelberg retina tomograph (HRT 3)), frequency-doubling technology perimetry (FDT), and complete ophthalmological examination. Based on ophthalmological clinical examination and FDT results of the worse eye, subjects were classified as either normal, possible glaucoma, and probable glaucoma or definitive glaucoma. RADAAR values were calculated based on stereometric HRT 3 values using different mathematical formulae. RADAAR-1 was calculated as a relative difference of rim and DAs between the eyes. RADAAR-2 was calculated by subtracting the value of rim to DA ratio of the smaller disc from the value of rim to DA ratio of the larger disc. RADAAR-3 was calculated by dividing the previous two values. Statistical analyses included ANOVA as well as Student t-tests.
Data of 334 participants were analysed, 78 of which were classified as definitive glaucoma. RADAAR-1 values were significantly different between the four different groups of diagnosis (F=5.82; P<0.001). The 1st and 99th percentile limits of normality for RADAAR-1, RADAAR-2, and RADAAR-3 in normal group were, respectively, -10.64 and 8.4; -0.32 and 0.22; and 0.58 and 1.32.
RADAAR-1 seems to best distinguish between the diagnostic groups. Knowledge of RADAAR distribution in various diagnostic groups may aid in clinical diagnosis of asymmetric glaucomatous damage.
描述不同的方法来分析边缘面积（RA）与盘面积（DA）不对称比（RADAAR）的双眼不对称性。
这是一项观察性、描述性和横断面研究。所有参与者的双眼均接受共焦激光扫描检眼镜（海德堡视网膜断层扫描仪（HRT 3））、频域光相干断层扫描（FDT）和全面眼科检查。根据眼科临床检查和较差眼的 FDT 结果，将受试者分为正常、可能青光眼、可疑青光眼和确诊青光眼。根据立体 HRT 3 值使用不同的数学公式计算 RADAAR 值。RADAAR-1 是通过比较双眼的边缘和 DA 之间的相对差异来计算的。RADAAR-2 通过从较小视盘的边缘到视盘的比率中减去较大视盘的边缘到视盘的比率来计算。RADAAR-3 通过将前两个值相除来计算。统计分析包括方差分析和学生 t 检验。
分析了 334 名参与者的数据，其中 78 名被诊断为确诊青光眼。在四个不同诊断组之间，RADAAR-1 值差异显著（F=5.82；P<0.001）。正常组中 RADAAR-1、RADAAR-2 和 RADAAR-3 的第 1 个和第 99 个百分位数正常范围分别为-10.64 和 8.4；-0.32 和 0.22；和 0.58 和 1.32。
RADAAR-1 似乎最能区分不同的诊断组。了解 RADAAR 在不同诊断组中的分布情况可能有助于临床诊断不对称性青光眼损伤。
