Amato Stephen, Man Heng-Ye
Department of Biology; Boston University; Boston, MA USA.
Cell Logist. 2011 May;1(3):103-105. doi: 10.4161/cl.1.3.16815.
Neuronal polarization begins by the selection of a single minor neurite that subsequently undergoes rapid extension until reaching a formidable length. To ensure that the highly active growth can be sustained by a sufficient energy supply, neurons are supposed to sense their energy status prior to initiating polarization. Our recent work shows that the bioenergy sensor, AMPK, plays a crucial role in the regulation of axon initiation. Activation of AMPK to mimic energy-lacking conditions results in a halt in axon selection and growth, leading to a loss of neuronal polarization.
神经元极化始于选择一条单一的小神经突，该神经突随后迅速延伸，直至达到相当长的长度。为确保高活性生长能够由充足的能量供应来维持，神经元理应在启动极化之前感知其能量状态。我们最近的研究表明，生物能量传感器AMPK在轴突起始的调控中起着关键作用。激活AMPK以模拟能量缺乏状态会导致轴突选择和生长停止，从而导致神经元极化丧失。
