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Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.环磷酸腺苷依赖性蛋白激酶参与白细胞介素-1的信号转导途径。
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Cyclic AMP--an intracellular second messenger for interleukin 1.环磷酸腺苷——白细胞介素1的细胞内第二信使。
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环磷酸腺苷依赖性蛋白激酶参与白细胞介素-1的信号转导途径。

Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.

作者信息

Chedid M, Mizel S B

机构信息

Department of Microbiology and Immunology, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.

出版信息

Mol Cell Biol. 1990 Jul;10(7):3824-7. doi: 10.1128/mcb.10.7.3824-3827.1990.

DOI:10.1128/mcb.10.7.3824-3827.1990
PMID:2192264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC360847/
Abstract

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

摘要

在白细胞介素-1（IL-1）应答细胞中，一种针对环磷酸腺苷（cAMP）依赖性蛋白激酶的高度特异性蛋白抑制剂的表达，阻断了由κ免疫球蛋白增强子或人类免疫缺陷病毒长末端重复序列驱动的IL-1诱导的基因转录。该抑制剂不影响蛋白激酶C介导的基因转录，这表明cAMP依赖性蛋白激酶在多种应答细胞类型中参与了IL-1的信号转导途径。