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肿瘤坏死因子α和β对HL60细胞中转录因子NF-κB的非环磷酸腺苷依赖性激活

Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.

作者信息

Hohmann H P, Kolbeck R, Remy R, van Loon A P

机构信息

Central Research Units, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

出版信息

Mol Cell Biol. 1991 Apr;11(4):2315-8. doi: 10.1128/mcb.11.4.2315-2318.1991.

DOI:10.1128/mcb.11.4.2315-2318.1991
PMID:1706475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC359939/
Abstract

No correlation exists in HL60 cells between NF-kappa B activation by tumor necrosis factor (TNF alpha) and TNF beta and intracellular levels of cyclic AMP. Cyclic AMP levels did not increase upon treatment of cells with each of these cytokines, although NF-kappa B was activated. Forskolin or 1-isobutyl-3-methylxanthine drastically increased intracellular levels of cyclic AMP, but neither activated NF-kappa B nor influenced TNF-induced NF-kappa B activation.

摘要

在HL60细胞中，肿瘤坏死因子（TNFα）和TNFβ激活核因子-κB（NF-κB）与细胞内环磷酸腺苷（cAMP）水平之间不存在相关性。尽管NF-κB被激活，但用这些细胞因子中的任何一种处理细胞后，cAMP水平并未升高。福斯高林或1-异丁基-3-甲基黄嘌呤可显著提高细胞内cAMP水平，但既不激活NF-κB，也不影响TNF诱导的NF-κB激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d185/359939/ff5ff813a997/molcellb00138-0552-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d185/359939/ff5ff813a997/molcellb00138-0552-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d185/359939/ff5ff813a997/molcellb00138-0552-a.jpg

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