转染的人类β-聚合酶启动子含有一个Ras反应元件。
Transfected human beta-polymerase promoter contains a ras-responsive element.
作者信息
Kedar P S, Lowy D R, Widen S G, Wilson S H
机构信息
Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892.
出版信息
Mol Cell Biol. 1990 Jul;10(7):3852-6. doi: 10.1128/mcb.10.7.3852-3856.1990.
beta-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human beta-polymerase promoter in a transient expression assay is activated by p21v-rasH expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.
β-聚合酶是一种脊椎动物细胞DNA聚合酶，参与某些类型的基因组DNA修复过程中的缺口填补合成。我们报告，在瞬时表达试验中，克隆的人β-聚合酶启动子在NIH 3T3细胞中被p21v-rasH表达激活。启动子中-49至-40位的一个十核苷酸回文元件GTGACGTCAC是这种ras介导的刺激所必需的。
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