控制黄喉姬鼠和小家鼠嗜亲性及嗜异性C型病毒受体的基因。
Genes controlling receptors for ecotropic and xenotropic type C virus in Mus cervicolor and Mus musculus.
作者信息
Marshall T H, Rapp U R
出版信息
J Virol. 1979 Feb;29(2):501-6. doi: 10.1128/JVI.29.2.501-506.1979.
Abstract
Gene loci controlling cell surface receptors for murine leukemia virus were studied by using murine X Chinese hamster hybrid cells. Hybrids which exclusively segregate murine chromosomes were made by fusing Mus cervicolor and Mus musculus lymphocytes to hamster fibroblasts. Sensitivity to Moloney murine leukemia virus infecotion and specific binding of the envelope glycoprotein of Rauscher murine leukemia virus (gp70) cosegregate and isozyme analysis show an association with chromosome 5 in both species. With the possible exception of one clone, no evidence was found for a proviral integration site independent of chromosome 5. Evidence is presented for additional unlinked ectropic and xenotropic receptors independent of chromosome 5.
摘要
利用小鼠与中国仓鼠杂交细胞对控制小鼠白血病病毒细胞表面受体的基因位点进行了研究。通过将中华姬鼠和小家鼠淋巴细胞与仓鼠成纤维细胞融合，制备了只分离小鼠染色体的杂交细胞。对莫洛尼小鼠白血病病毒感染的敏感性以及劳氏肉瘤病毒包膜糖蛋白（gp70）的特异性结合共分离，同工酶分析表明在两个物种中均与5号染色体有关联。除了一个克隆可能例外，未发现与5号染色体无关的前病毒整合位点的证据。文中提供了与5号染色体无关的其他不连锁嗜异性和异嗜性受体的证据。
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本文引用的文献
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Detection and quantitation of phenotypically mixed viruses: mixing of ecotropic and xenotropic murine leukemia viruses.表型混合病毒的检测与定量：亲嗜性和异嗜性鼠白血病病毒的混合
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