树突状细胞发育中的转录因子网络。
Transcription factor networks in dendritic cell development.
机构信息
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
出版信息
Semin Immunol. 2011 Oct;23(5):388-97. doi: 10.1016/j.smim.2011.08.009. Epub 2011 Sep 15.
Abstract
Dendritic cells (DCs) are a heterogeneous population within the mononuclear phagocyte system (MPS) that derive from bone marrow precursors. Commitment and specification of hematopoietic progenitors to the DC lineage is critical for the proper induction of both immunity and tolerance. This review summarizes the important cytokines and transcription factors required for differentiation of the DC lineage as well as further diversification into specific DC subsets. We highlight recent advances in the characterization of immediate DC precursors arising from the common myeloid progenitor (CMP). Particular emphasis is placed on the corresponding temporal expression of relevant factors involved in regulating developmental options.
摘要
树突状细胞 (DCs) 是单核吞噬细胞系统 (MPS) 中的一个异质性群体，来源于骨髓前体。造血祖细胞向 DC 谱系的定向分化和定型对于诱导免疫和耐受都是至关重要的。本综述总结了 DC 谱系分化以及进一步分化为特定 DC 亚群所必需的重要细胞因子和转录因子。我们强调了在鉴定来自共同髓系前体 (CMP) 的即刻 DC 前体方面的最新进展。特别强调了相关因子在调节发育选择方面的相应时间表达。
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