• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Transcription factor networks in dendritic cell development.树突状细胞发育中的转录因子网络。
Semin Immunol. 2011 Oct;23(5):388-97. doi: 10.1016/j.smim.2011.08.009. Epub 2011 Sep 15.
2
Dendritic cell development-History, advances, and open questions.树突状细胞发育——历史、进展和悬而未决的问题。
Semin Immunol. 2015 Dec;27(6):388-96. doi: 10.1016/j.smim.2016.03.012. Epub 2016 Mar 31.
3
Re(de)fining the dendritic cell lineage.重新定义树突状细胞谱系。
Nat Immunol. 2012 Dec;13(12):1145-54. doi: 10.1038/ni.2467. Epub 2012 Nov 16.
4
Transcriptional programming of the dendritic cell network.树突状细胞网络的转录编程。
Nat Rev Immunol. 2012 Jan 25;12(2):101-13. doi: 10.1038/nri3149.
5
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow.人类脐带血和骨髓中受限的树突状细胞和单核细胞祖细胞。
J Exp Med. 2015 Mar 9;212(3):385-99. doi: 10.1084/jem.20141442. Epub 2015 Feb 16.
6
A common pathway for dendritic cell and early B cell development.树突状细胞和早期B细胞发育的共同途径。
J Immunol. 2001 Aug 1;167(3):1387-92. doi: 10.4049/jimmunol.167.3.1387.
7
Deciphering the transcriptional network of the dendritic cell lineage.解析树突状细胞谱系的转录网络。
Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.
8
Positive and negative regulation of the myeloid dendritic cell lineage.髓样树突状细胞谱系的正负调控
J Leukoc Biol. 1999 Aug;66(2):209-16. doi: 10.1002/jlb.66.2.209.
9
Plasticity in the transcriptional and epigenetic circuits regulating dendritic cell lineage specification and function.调节树突状细胞谱系特化和功能的转录及表观遗传回路中的可塑性。
Curr Opin Immunol. 2014 Oct;30:1-8. doi: 10.1016/j.coi.2014.04.004. Epub 2014 May 13.
10
Hemopoietic precursors and development of dendritic cell populations.造血前体细胞与树突状细胞群体的发育
Leuk Lymphoma. 2003 Sep;44(9):1469-75. doi: 10.3109/10428190309178766.

引用本文的文献

1
Progress in the development of cancer vaccines for lung cancer utilizing dendritic cells (Review).利用树突状细胞开发肺癌癌症疫苗的进展（综述）
Oncol Lett. 2025 Apr 14;29(6):298. doi: 10.3892/ol.2025.15044. eCollection 2025 Jun.
2
Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis.B细胞淋巴瘤/白血病11A在正常和恶性造血中的作用。
Biology (Basel). 2025 Jan 1;14(1):26. doi: 10.3390/biology14010026.
3
The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity.AP-1 转录因子 c-Jun 和 JunB 对于 CD8α 常规树突状细胞的特性是必需的。
Cell Death Differ. 2021 Aug;28(8):2404-2420. doi: 10.1038/s41418-021-00765-4. Epub 2021 Mar 23.
4
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.转录因子 C/EBPβ 在稳态和恶性条件下协调树突状细胞的成熟和功能。
Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26328-26339. doi: 10.1073/pnas.2008883117. Epub 2020 Oct 5.
5
Myeloid and Plasmacytoid Dendritic Cells and Cancer - New Insights.髓样和浆细胞样树突状细胞与癌症——新见解
Open Access Maced J Med Sci. 2019 Oct 13;7(19):3324-3340. doi: 10.3889/oamjms.2019.735. eCollection 2019 Oct 15.
6
Human Tumor-Infiltrating Dendritic Cells: From in Situ Visualization to High-Dimensional Analyses.人类肿瘤浸润性树突状细胞：从原位可视化到高维分析
Cancers (Basel). 2019 Jul 30;11(8):1082. doi: 10.3390/cancers11081082.
7
Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.利什曼病中树突状细胞激活的分子机制：一种免疫生物学观点。
Front Immunol. 2019 Feb 22;10:227. doi: 10.3389/fimmu.2019.00227. eCollection 2019.
8
Importance of EMT Factor ZEB1 in cDC1 "MutuDC Line" Mediated Induction of Th1 Immune Response.EMT 因子 ZEB1 在 cDC1“MutuDC 系”介导的 Th1 免疫应答中的重要性。
Front Immunol. 2018 Nov 13;9:2604. doi: 10.3389/fimmu.2018.02604. eCollection 2018.
9
The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture.造血的发生：发育起源与环境培育。
Int J Mol Sci. 2018 Jul 21;19(7):2122. doi: 10.3390/ijms19072122.
10
An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.中性粒细胞-树突状细胞杂合细胞在抗侵袭性真菌感染免疫中的未被重视的作用。
PLoS Pathog. 2018 May 21;14(5):e1007073. doi: 10.1371/journal.ppat.1007073. eCollection 2018 May.

本文引用的文献

1
Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells.转录因子 e2-2 的持续表达维持了成熟浆细胞样树突状细胞的细胞命运。
Immunity. 2010 Dec 14;33(6):905-16. doi: 10.1016/j.immuni.2010.11.023. Epub 2010 Dec 9.
2
Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells.Bcl6 对于小鼠 CD4+ 和 CD8α+ 树突状细胞的发育是必需的。
J Immunol. 2011 Jan 1;186(1):255-63. doi: 10.4049/jimmunol.0903714. Epub 2010 Dec 3.
3
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.浆细胞样树突状细胞消融会影响早期干扰素反应和抗病毒 NK 及 CD8(+)T 细胞的积累。
Immunity. 2010 Dec 14;33(6):955-66. doi: 10.1016/j.immuni.2010.11.020. Epub 2010 Dec 2.
4
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.微生物刺激可使单核细胞完全分化为表达 DC-SIGN/CD209(+)的树突状细胞，用于免疫 T 细胞区。
Cell. 2010 Oct 29;143(3):416-29. doi: 10.1016/j.cell.2010.09.039.
5
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.雷帕霉素靶蛋白在 Flt3 配体信号下游控制树突状细胞发育。
Immunity. 2010 Oct 29;33(4):597-606. doi: 10.1016/j.immuni.2010.09.012. Epub 2010 Oct 7.
6
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.TGF-β1 可加速普通树突状细胞前体细胞向树突状细胞的分化，并将其亚群特化方向指向传统树突状细胞。
J Immunol. 2010 Nov 1;185(9):5326-35. doi: 10.4049/jimmunol.0903950. Epub 2010 Sep 29.
7
Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen.炎性树突状细胞而非嗜碱性粒细胞对于诱导吸入性屋尘螨变应原的 Th2 免疫应答是必需且充分的。
J Exp Med. 2010 Sep 27;207(10):2097-111. doi: 10.1084/jem.20101563. Epub 2010 Sep 6.
8
Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.抗原摄取途径对树突状细胞和激活的单核细胞的呈递有不同的影响。
J Immunol. 2010 Sep 15;185(6):3426-35. doi: 10.4049/jimmunol.1001205. Epub 2010 Aug 20.
9
Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.β-连环蛋白在树突状细胞中的激活调节肠道中的免疫与耐受。
Science. 2010 Aug 13;329(5993):849-53. doi: 10.1126/science.1188510.
10
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.CX3CR1+CD8α+树突状细胞是与浆细胞样树突状细胞相关的稳定群体。
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14745-50. doi: 10.1073/pnas.1001562107. Epub 2010 Aug 2.

树突状细胞发育中的转录因子网络。

Transcription factor networks in dendritic cell development.

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

出版信息

Semin Immunol. 2011 Oct;23(5):388-97. doi: 10.1016/j.smim.2011.08.009. Epub 2011 Sep 15.

DOI:10.1016/j.smim.2011.08.009
PMID:21924924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4010935/
Abstract

Dendritic cells (DCs) are a heterogeneous population within the mononuclear phagocyte system (MPS) that derive from bone marrow precursors. Commitment and specification of hematopoietic progenitors to the DC lineage is critical for the proper induction of both immunity and tolerance. This review summarizes the important cytokines and transcription factors required for differentiation of the DC lineage as well as further diversification into specific DC subsets. We highlight recent advances in the characterization of immediate DC precursors arising from the common myeloid progenitor (CMP). Particular emphasis is placed on the corresponding temporal expression of relevant factors involved in regulating developmental options.

摘要

树突状细胞 (DCs) 是单核吞噬细胞系统 (MPS) 中的一个异质性群体，来源于骨髓前体。造血祖细胞向 DC 谱系的定向分化和定型对于诱导免疫和耐受都是至关重要的。本综述总结了 DC 谱系分化以及进一步分化为特定 DC 亚群所必需的重要细胞因子和转录因子。我们强调了在鉴定来自共同髓系前体 (CMP) 的即刻 DC 前体方面的最新进展。特别强调了相关因子在调节发育选择方面的相应时间表达。