Department of Public Health, Keimyung University, Daegu, Republic of Korea.
Environ Res. 2011 Nov;111(8):1280-5. doi: 10.1016/j.envres.2011.09.003. Epub 2011 Sep 16.
Bisphenol A (BPA) and triclosan are synthetic phenolic compounds to which the general public can be extensively exposed via consumer products and environmental contamination. In this study, we assessed exposure to BPA and triclosan in the Korean adult population aged 18-69 based on the Korean National Human Biomonitoring Survey conducted in 2009. Relying on data from 1870 representative Koreans, we found that the geometric mean urinary concentrations of BPA and triclosan were 1.90 ng/ml [95% confidence interval (CI): 1.81-1.99] and 1.68 ng/ml (95% CI: 1.48-1.90), respectively. The creatinine-adjusted geometric means of BPA and triclosan were 1.79 μg/g creatinine (95% CI: 1.70-1.90) and 1.58 μg/g creatinine (95% CI: 1.39-1.81), respectively. About 99.8% of the Korean adult population had urinary concentrations of BPA and about 92.6% of the Korean adult population had urinary concentrations of triclosan above the level of 0.05 ng/ml (limit of detection, LOD). Urinary BPA concentrations were higher in residents of rural areas, whereas urinary triclosan concentrations were significantly associated with cigarette smoking. These findings suggested that most Koreans had detectable levels of BPA and triclosan in their urine and that the body burden of BPA and triclosan varied according to demographic and geographic factors.
双酚 A（BPA）和三氯生是两种合成酚类化合物，公众可以通过消费产品和环境污染广泛接触到它们。在这项研究中，我们根据 2009 年进行的韩国全国人体生物监测调查，评估了 18-69 岁韩国成年人接触 BPA 和三氯生的情况。依靠来自 1870 名代表性韩国人的数据，我们发现 BPA 和三氯生的尿中浓度几何平均值分别为 1.90ng/ml（95%置信区间：1.81-1.99）和 1.68ng/ml（95%置信区间：1.48-1.90）。BPA 和三氯生的尿中浓度经肌酐校正后的几何平均值分别为 1.79μg/g 肌酐（95%置信区间：1.70-1.90）和 1.58μg/g 肌酐（95%置信区间：1.39-1.81）。约 99.8%的韩国成年人的尿液中含有 BPA，约 92.6%的韩国成年人的尿液中含有三氯生，其浓度超过 0.05ng/ml（检出限，LOD）。农村地区居民的尿液中 BPA 浓度较高，而尿液中三氯生浓度与吸烟显著相关。这些发现表明，大多数韩国人尿液中可检测到 BPA 和三氯生的存在，而且 BPA 和三氯生的体内负荷因人口统计学和地理因素而异。
