School of Engineering, Brown University, Providence, Rhode Island 02912, USA.
Phys Rev Lett. 2011 Aug 26;107(9):098101. doi: 10.1103/PhysRevLett.107.098101. Epub 2011 Aug 22.
A fundamental understanding of cell-nanomaterial interaction is of essential importance to nanomedicine and safe applications of nanotechnology. Here we investigate the adhesive wrapping of a soft elastic vesicle by a lipid membrane. We show that there exist a maximum of five distinct wrapping phases based on the stability of full wrapping, partial wrapping, and no wrapping states. The wrapping phases depend on the vesicle size, adhesion energy, surface tension of membrane, and bending rigidity ratio between vesicle and membrane. These results are of immediate interest to the study of vesicular transport and endocytosis or phagocytosis of elastic particles into cells.
对细胞-纳米材料相互作用的基本理解对于纳米医学和纳米技术的安全应用至关重要。在这里，我们研究了软弹性囊泡被脂质膜的粘性包裹。我们表明，基于完全包裹、部分包裹和不包裹状态的稳定性，存在最多五个不同的包裹相。包裹相取决于囊泡大小、粘附能、膜表面张力和囊泡与膜之间的弯曲刚度比。这些结果对囊泡运输以及弹性颗粒进入细胞的内吞或吞噬的研究具有直接的兴趣。
