School of Engineering, Brown University, Providence, Rhode Island 02912, USA.
Soft Matter. 2015 Feb 14;11(6):1107-15. doi: 10.1039/c4sm02427c.
Nanocapsules that can be tailored intelligently and specifically have drawn considerable attention in the fields of drug delivery and bioimaging. Here we conduct a theoretical study on cell uptake of a spherical nanocapsule which is modeled as a linear elastic solid thin shell in three dimensions. It is found that there exist five wrapping phases based on the stability of three wrapping states: no wrapping, partial wrapping and full wrapping. The wrapping phase diagrams are strongly dependent on the capsule size, adhesion energy, cell membrane tension, and bending rigidity ratio between the capsule and membrane. Discussion is made on similarities and differences between the cell uptake of solid nanocapsules and fluid vesicles. The reported results may have important implications for biomedical applications of nanotechnology.
智能且特异定制的纳米胶囊在药物输送和生物成像领域引起了相当大的关注。在这里，我们对一个球形纳米胶囊的细胞摄取进行了理论研究，该纳米胶囊被建模为三维中的线性弹性固体薄壳。结果发现，基于三种包裹状态的稳定性，存在五种包裹相：无包裹、部分包裹和完全包裹。包裹相图强烈依赖于胶囊尺寸、粘附能、细胞膜张力以及胶囊与膜之间的弯曲刚度比。讨论了固体纳米胶囊和流体囊泡的细胞摄取之间的异同。所报道的结果可能对纳米技术的生物医学应用具有重要意义。
