Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Neurosci Bull. 2011 Oct;27(5):325-9. doi: 10.1007/s12264-011-1531-5.
Exercise is known to enhance circulating brain-derived neurotrophic factor (BDNF) levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration.
Brazilian sprinters (100 m) at either the international (Olympics and Outdoor World Championships) (n = 14) or the domestic level (n = 8), and sedentary subjects (n = 15), were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay.
The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level.
Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.
运动已知可增强健康人群的循环脑源性神经营养因子（BDNF）水平。已经测量了耐力运动但不是力量运动中的 BDNF 变化。本研究旨在调查诸如短跑等无氧活动是否会使基础血浆 BDNF 浓度产生差异。
招募了国际级（奥运会和室外世界锦标赛）（n = 14）或国家级（n = 8）的巴西短跑运动员（100 米）和久坐不动的受试者（n = 15）。通过酶联免疫吸附试验分析血浆 BDNF 浓度。
国际级和国家级短跑运动员的基础血浆 BDNF 浓度明显高于久坐不动的受试者。此外，国际级短跑运动员的血浆 BDNF 浓度高于国家级短跑运动员。
我们的研究结果表明，基础血浆 BDNF 水平的升高与运动表现的提高有关。
