Vézina D, Sheridan P, Blain R, Roberts K D, Bleau G
Maisonneuve-Rosemont Research Center, University of Montreal, Quebec, Canada.
Contraception. 1990 Jun;41(6):605-16. doi: 10.1016/s0010-7824(09)91005-8.
The majority of vasectomized men develop antibodies against different sperm antigens, including protamine. Due to the fact that salmon protamine is used clinically for heparin reversal and that a cross-reactivity has been observed between human and salmon protamine, vasectomized men may be at risk for adverse reactions to protamine sulfate. In order to explore this possibility, serum samples were analyzed for the presence of anti-sperm and anti-protamine antibodies in 20 vasectomized and 20 non-vasectomized men (controls) about to undergo major heart surgery requiring heparin reversal. The patients were closely monitored for any possible reaction following the injection of protamine. Anti-sperm antibodies were detected in the serum of 15 of the vasectomized men whereas only two of the non-vasectomized subjects had this type of antibody. Twenty-five percent of the vasectomized men presented with anti-protamine antibodies; in the control group, none of the patients had developed this type of antibody. Following the administration of protamine sulfate, none of the patients in either group showed any adverse reaction to the drug. It is concluded that vasectomized men are not at increased risk towards adverse reactions following the injection of protamine sulfate.
大多数接受输精管切除术的男性会产生针对不同精子抗原的抗体，包括鱼精蛋白。由于鲑鱼鱼精蛋白在临床上用于肝素逆转，并且已观察到人类和鲑鱼鱼精蛋白之间存在交叉反应，接受输精管切除术的男性可能有对硫酸鱼精蛋白产生不良反应的风险。为了探究这种可能性，对20名即将接受需要肝素逆转的心脏大手术的输精管切除男性和20名未接受输精管切除术的男性（对照组）的血清样本进行了抗精子和抗鱼精蛋白抗体检测。在注射鱼精蛋白后，对患者进行密切监测，观察是否有任何可能的反应。在15名输精管切除男性的血清中检测到抗精子抗体，而未接受输精管切除术的受试者中只有两人有这种类型的抗体。25%的输精管切除男性出现抗鱼精蛋白抗体；在对照组中，没有患者产生这种类型的抗体。注射硫酸鱼精蛋白后，两组患者均未出现对该药物的任何不良反应。结论是，输精管切除男性在注射硫酸鱼精蛋白后发生不良反应的风险并未增加。
