不育男性、输精管切除男性及猴子血清中与鲑鱼精蛋白和人精蛋白发生反应的抗体。
Antibodies reacting with salmon and human protamines in sera from infertile men and from vasectomized men and monkeys.
作者信息
Samuel T
出版信息
Clin Exp Immunol. 1977 Nov;30(2):181-7.
Abstract
A micro-complement fixation test was modified for the detection of low-titred antibodies to protamines. Specific immunological reactions with salmon protamine were found with some sera obtained from infertile men and vasectomized men and monkeys. The possibilities that allergic reactions, observed in patients receiving salmon protamine, result from immunity to the fish protamine and from immunological cross-reaction between human and salmon protamines (in cases where auto-immunity to human protamine has developed prior to the administration of fish protamine) are discussed.
摘要
改良了微量补体结合试验以检测对鱼精蛋白的低滴度抗体。在一些来自不育男性、输精管切除男性和猴子的血清中发现了与鲑鱼鱼精蛋白的特异性免疫反应。讨论了接受鲑鱼鱼精蛋白的患者中观察到的过敏反应是由对鱼精蛋白的免疫以及人类和鲑鱼鱼精蛋白之间的免疫交叉反应（在给予鱼精蛋白之前已产生对人类鱼精蛋白的自身免疫的情况下）引起的可能性。
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