减毒活疫苗（OPV）诱导的病毒干扰可预防中耳炎。
Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.
机构信息
Department of Virology, University of Tampere, Tampere, Finland.
出版信息
Vaccine. 2011 Nov 3;29(47):8615-8. doi: 10.1016/j.vaccine.2011.09.015. Epub 2011 Sep 20.
BACKGROUND
The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.
METHODS
Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months.
RESULTS
Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR=0.76 [95% CI 0.59-0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P=0.003).
CONCLUSIONS
OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.
背景
本研究旨在评估减毒活脊髓灰质炎疫苗（OPV）是否对引起幼儿中耳炎的非脊髓灰质炎感染具有临床相关的干扰作用。
方法
开放性试验中，干预组（64 名儿童）在 2、3、6 和 12 个月时接种 OPV，对照组（250 名儿童）在 6 和 12 个月时接种 IPV（灭活脊髓灰质炎疫苗）。在 3、6、12、18 和 24 个月时通过问卷记录临床症状。
结果
中耳炎发作在 OPV 组比对照组更为少见。6-18 个月时差异具有统计学意义（IRR=0.76 [95% CI 0.59-0.94]，P=0.011），且在入托儿童中更为明显（IRR 0.37 [95% CI 0.19-0.71]，P=0.003）。
结论
OPV 可提供一定程度的中耳炎保护。这种作用可能是通过病毒对非脊髓灰质炎病毒的干扰介导的。
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