自由生活微生物中的密码子偏好性。
Codon preferences in free-living microorganisms.
作者信息
Andersson S G, Kurland C G
机构信息
Department of Molecular Biology, Uppsala University Biomedical Center, Sweden.
出版信息
Microbiol Rev. 1990 Jun;54(2):198-210. doi: 10.1128/mr.54.2.198-210.1990.
Abstract
A popular interpretation of the major codon preference is that it reflects the operation of a regulatory device that controls the expression of individual proteins. In this popular model, rapidly translated codons are thought to promote the accumulation of the highly expressed proteins and slowly translated codons are thought to retard the expression of poorly expressed proteins. However, this widely accepted model is not supported by kinetic theory or by experimental results. A less fashionable model in which the major codon preference has nothing to do with the expression level of the individual proteins is forwarded. In this model, the major codon preference is viewed as a global strategy to support the efficient function of the translation system and thereby to maximize the growth rates of cells under favorable conditions.
摘要
对主要密码子偏好的一种普遍解释是，它反映了一种调控机制的运作，该机制控制着单个蛋白质的表达。在这个流行的模型中，快速翻译的密码子被认为能促进高表达蛋白质的积累，而缓慢翻译的密码子则被认为会抑制低表达蛋白质的表达。然而，这个被广泛接受的模型并未得到动力学理论或实验结果的支持。一种不太流行的模型被提出，在这个模型中，主要密码子偏好与单个蛋白质的表达水平无关。在这个模型中，主要密码子偏好被视为一种全局策略，以支持翻译系统的高效功能，从而在有利条件下最大化细胞的生长速率。
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