Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Nat Rev Immunol. 2011 Sep 23;11(10):693-702. doi: 10.1038/nri3063.
As Nature Reviews Immunology reaches its 10(th) anniversary, the authors of one of the top-cited articles from each year take a trip down memory lane. We've asked them to look back on the state of research at the time their Review was published, to consider why the article has had the impact it has and to discuss the future directions of their field. This Viewpoint article provides an interesting snapshot of some of the fundamental advances in immunology over the past 10 years. Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10. The complexities in the development and heterogeneity of macrophages, dendritic cells and T helper cells continue to engage immunologists, as do the immune processes involved in diseases such as atherosclerosis. We look forward to what the next 10 years of immunology research may bring.
在《自然评论免疫学》迎来创刊 10 周年之际，我们邀请了每一年中被引用最多的文章的作者之一，回顾一下他们的综述发表时的研究状况。我们请他们反思这篇综述产生如此大影响的原因，并探讨他们所在领域的未来方向。这篇观点文章为我们提供了一个有趣的视角，让我们了解过去 10 年中免疫学的一些重要进展。其中的亮点包括我们对 Toll 样受体信号转导的理解的提高，以及对调节性 T 细胞、吲哚胺 2,3-双加氧酶、髓系来源的抑制细胞和白细胞介素 10 介导的免疫调节的理解。巨噬细胞、树突状细胞和 T 辅助细胞的发育和异质性的复杂性仍然是免疫学家关注的焦点，动脉粥样硬化等疾病中涉及的免疫过程也是如此。我们期待未来 10 年的免疫学研究可能带来的成果。
