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在土拨鼠肝炎病毒诱导的肝细胞癌模型中谷胱甘肽/眼氨酸氧化还原缓冲系统的紊乱

Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma.

作者信息

Andres Ibarra Rafael, Abbas R, Kombu R S, Zhang Guo-Fang, Jacobs G, Lee Z, Brunengraber H, Sanabria J R

机构信息

Department of Surgery, Case Western Reserve University School of Medicine and University Hospitals, Case Medical Center, Cleveland, OH 44106-7029, USA.

出版信息

HPB Surg. 2011;2011:789323. doi: 10.1155/2011/789323. Epub 2011 Sep 18.

DOI:10.1155/2011/789323
PMID:21941408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3175733/
Abstract

Purpose. The incidence of liver tumors is rising in USA. The purpose of this study was to evaluate liver oxido-reductive status in the presence of chronic liver disease and hepatocellular carcinoma (HCC). Methods. Glutathione species and ophthalmate (OA) concentrations were measured by LC-MS in processed plasma and red blood cells (RBC) from infected Woodchuck with hepatitis virus (WHV). Blood samples were obtained from: (i) infected animals with tumors (WHV+/HCC+), (ii) infected animals without tumors (WHV+/HCC-) and (iii) healthy animals (WHC-/HCC-). Results. The concentration of reduced glutathione (GSH) and the ratio GSH/GSG were lower in plasma from WHV+/HCC+ animals when compared to WHV+/HCC- and WHV-/HCC- (P < 0.01). In contrast, the concentration of oxidized glutathione (GSSG) was found to be higher in plasma from WHV+/HCC+ animals when compared to WHV+/HCC- and WHV-/HCC- (P < 0.01). The Glutathione species and its ratio from the RBC compartment were similar among all groups. OA concentration in both plasma and RBC was significantly higher from WHV+/HCC+ when compared to WHV+/HCC- and WHV-/HCC- (P < 0.01). Conclusions. Disturbances of the glutathione redox buffer system and higher concentrations of OA were found in the WCV+/HCC+ animal model. The role of these compounds as biomarkers of early tumor development in patients with end stage liver disease remains to be determined.

摘要

目的。在美国，肝肿瘤的发病率正在上升。本研究的目的是评估慢性肝病和肝细胞癌（HCC）存在时肝脏的氧化还原状态。方法。通过液相色谱 - 质谱法测量感染土拨鼠肝炎病毒（WHV）的处理后血浆和红细胞（RBC）中的谷胱甘肽种类和羟脯氨酸（OA）浓度。血液样本取自：（i）患有肿瘤的感染动物（WHV + / HCC +），（ii）未患肿瘤的感染动物（WHV + / HCC -）和（iii）健康动物（WHC - / HCC -）。结果。与WHV + / HCC - 和WHC - / HCC - 相比，WHV + / HCC + 动物血浆中还原型谷胱甘肽（GSH）的浓度以及GSH / GSG的比率较低（P < 0.01）。相反，与WHV + / HCC - 和WHC - / HCC - 相比，发现WHV + / HCC + 动物血浆中氧化型谷胱甘肽（GSSG）的浓度较高（P < 0.01）。所有组中红细胞部分的谷胱甘肽种类及其比率相似。与WHV + / HCC - 和WHC - / HCC - 相比，WHV + / HCC + 的血浆和红细胞中的OA浓度均显著更高（P < 0.01）。结论。在WCV + / HCC + 动物模型中发现了谷胱甘肽氧化还原缓冲系统的紊乱和较高的OA浓度。这些化合物作为终末期肝病患者早期肿瘤发展生物标志物的作用仍有待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/3613deb4f2f3/HPB2011-789323.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/ade00b2fe1d0/HPB2011-789323.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/0e0f6ae5e056/HPB2011-789323.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/ebefd8a7eefa/HPB2011-789323.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/9e7c3775d0fb/HPB2011-789323.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/52e1e1184cb7/HPB2011-789323.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/3613deb4f2f3/HPB2011-789323.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/ade00b2fe1d0/HPB2011-789323.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/0e0f6ae5e056/HPB2011-789323.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/ebefd8a7eefa/HPB2011-789323.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/9e7c3775d0fb/HPB2011-789323.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/52e1e1184cb7/HPB2011-789323.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6804/3175733/3613deb4f2f3/HPB2011-789323.006.jpg

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