Locatelli Marcello, Epifano Francesco, Genovese Salvatore, Carlucci Giuseppe, Koncić Marijana Zovko, Kosalec Ivan, Kremer Dario
Dipartimento di Scienze del Farmaco, Università degli Studi "G. D'Annunzio" di Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Nat Prod Commun. 2011 Sep;6(9):1275-80.
The anthraquinone profile, antioxidant and antimicrobial activities as well as the total phenol and total flavonoid contents were determined in methanol extracts of the barks of Rhamnus catharticus L. and R. orbiculatus Bornm. The most abundant anthraquinone derivatives in R. catharticus were physcion (67.8%) and emodin (26.2%), while R. orbiculatus contained mostly physcion (81.3%) and chrysophanol (14.6%). R. catharticus displayed better activity in the beta-carotene-linoleic acid assay, as well as chelating activity, whereas its activity in the reducing power assay was significantly lower than that of R. orbiculatus. Both methanol extracts showed antimicrobial activity against all microbial species tested (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Aspergillus niger, Microsporum gypseum) with MIC values either equal to or lower than 2.50 mg/mL. R. catharticus and R. orbiculatus contained several anthranoid aglycones and their bark extracts demonstrated notable antioxidant and antimicrobial properties. The results obtained indicate the medicinal potential of these two species.
测定了鼠李（Rhamnus catharticus L.）和圆叶鼠李（R. orbiculatus Bornm.）树皮甲醇提取物中的蒽醌谱、抗氧化和抗菌活性以及总酚和总黄酮含量。鼠李中含量最丰富的蒽醌衍生物是大黄素甲醚（67.8%）和大黄素（26.2%），而圆叶鼠李主要含有大黄素甲醚（81.3%）和大黄酚（14.6%）。鼠李在β-胡萝卜素-亚油酸测定以及螯合活性方面表现出更好的活性，但其在还原能力测定中的活性明显低于圆叶鼠李。两种甲醇提取物对所有测试的微生物物种（金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌、白色念珠菌、黑曲霉、石膏样小孢子菌）均显示出抗菌活性，最低抑菌浓度（MIC）值等于或低于2.50 mg/mL。鼠李和圆叶鼠李含有多种蒽酚苷元，其树皮提取物表现出显著的抗氧化和抗菌特性。所获得的结果表明这两个物种具有药用潜力。
