Noguchi T, Izumizawa K, Fukuda M, Kitamura S, Suzuki Y, Ikura H
Bull Tokyo Med Dent Univ. 1984 Sep;31(3):145-53.
A new method for local drug delivery to the subgingival plaque was developed using hydroxypropylcellulose (HPC) as a base material. Using this material prepared in the form of strips containing antimicrobial drugs, the clinical and microbiological effects by this method on the human periodontal disease were studied. Before the clinical trials, the rate of the drug release from the strips was studied. Both drugs used in this study (CH: chlorhexidine and TC: tetracycline) were released almost within 2 hours from the strips in vitro. In the gingival crevicular fluid, however, it was found that the TC was maintained for 24 hours after the local delivery. Five patients who had deep pockets contralaterally were selected. The CH-containing HPC strips (5%) were applied in one pocket of each patient and the placebo strips were applied in other pocket on day 0, 2 and 4. Plaque Index, Gingival Index, probing depth and the presence or absence of bleeding on probing were recorded on day 0, 2, 4 and 6. Marked reduction of bleeding on probing was found in the pockets applied the CH-containing HPC strips. There was a significant reduction in the proportion of Bacteroides asaccharolyticus in these pockets (p less than 0.01).
开发了一种以羟丙基纤维素（HPC）为基础材料向龈下菌斑局部给药的新方法。使用以含有抗菌药物的条带形式制备的这种材料，研究了该方法对人类牙周病的临床和微生物学效果。在进行临床试验之前，研究了药物从条带中的释放速率。本研究中使用的两种药物（CH：洗必泰，TC：四环素）在体外几乎在2小时内从条带中释放出来。然而，在龈沟液中发现，局部给药后TC可维持24小时。选择了5例对侧有深牙周袋的患者。在第0、2和4天，将含CH的HPC条带（5%）应用于每位患者的一个牙周袋，将安慰剂条带应用于另一个牙周袋。在第0、2、4和6天记录菌斑指数、牙龈指数、探诊深度和探诊出血情况。在应用含CH的HPC条带的牙周袋中发现探诊出血明显减少。这些牙周袋中解糖嗜胨菌的比例显著降低（p<0.01）。
