Polin R A
Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia.
Rev Infect Dis. 1990 May-Jun;12 Suppl 4:S428-38. doi: 10.1093/clinids/12.supplement_4.s428.
Fibronectin is a large-molecular-weight glycoprotein present on most cell surfaces, in extracellular fluids, and in plasma. Both cell-associated and soluble fibronectin are thought to have important roles in the inflammatory response and host defense and may contribute to the maintenance of microvascular integrity during septic episodes. Newborn infants have levels of fibronectin in plasma that are one-third to one-half those found in the healthy adult. In addition, neonates with respiratory distress syndrome, perinatal asphyxia, bacterial sepsis, intrauterine growth retardation, or postnatal malnutrition have a further depression in their plasma levels of fibronectin. The low plasma concentration of fibronectin in newborn infants may contribute to the hypofunction of the neonatal reticuloendothelial system and predispose to the development of sepsis. Rates of synthesis of plasma fibronectin are diminished in the neonate, and an inverse correlation between fibronectin half-life and gestational age exists. The role of fibronectin in treatment or prophylaxis of neonatal sepsis remains to be determined.
纤连蛋白是一种大分子糖蛋白，存在于大多数细胞表面、细胞外液和血浆中。细胞相关纤连蛋白和可溶性纤连蛋白都被认为在炎症反应和宿主防御中起重要作用，并且可能有助于在脓毒症发作期间维持微血管完整性。新生儿血浆中的纤连蛋白水平是健康成年人的三分之一到二分之一。此外，患有呼吸窘迫综合征、围产期窒息、细菌性败血症、宫内生长迟缓或出生后营养不良的新生儿，其血浆纤连蛋白水平会进一步降低。新生儿血浆中纤连蛋白浓度低可能导致新生儿网状内皮系统功能减退，并易患败血症。新生儿血浆纤连蛋白的合成速率降低，且纤连蛋白半衰期与胎龄呈负相关。纤连蛋白在新生儿败血症治疗或预防中的作用仍有待确定。
