败血症早产儿血浆纤连蛋白浓度降低。
Decreased plasma fibronectin concentrations in preterm infants with septicaemia.
作者信息
Dyke M P, Forsyth K D
机构信息
Department of Newborn Services, King Edward Memorial Hospital for Women, Perth, Western Australia.
出版信息
Arch Dis Child. 1993 May;68(5 Spec No):557-60. doi: 10.1136/adc.68.5_spec_no.557.
Changes in plasma fibronectin concentrations were determined during bacterial septicaemia in extremely preterm infants. The study was a prospective study of fibronectin concentrations in infants of less than 30 weeks' gestation. Concentrations were determined at birth, before sepsis, and throughout the episode of sepsis. Fibronectin concentrations at birth or immediately before sepsis were not significantly different between those infants who developed septicaemia and those who did not (98 (15) v 97 (10) micrograms/ml). In the infants with septicaemia, fibronectin concentrations decreased significantly on day 1 (106 (13) v 173 (18) micrograms/ml for the controls) and remained significantly lower on day 2 (123 (26) v 201 (17) micrograms/ml). By day 5 fibronectin concentrations had increased and were no longer statistically different from controls. Fibronectin is a key modulator of the immune response, with important functions in neutrophil adhesion, bacterial opsonisation, T cell activation, and vascular integrity. Acute depletion of plasma fibronectin during sepsis in preterm neonates may further abrogate their ability to control sepsis.
在极早产儿发生细菌性败血症期间，测定血浆纤连蛋白浓度。该研究是一项针对孕周小于30周婴儿纤连蛋白浓度的前瞻性研究。在出生时、败血症发生前以及败血症整个病程中测定浓度。发生败血症的婴儿与未发生败血症的婴儿在出生时或败血症即将发生前的纤连蛋白浓度无显著差异（98（15）对97（10）微克/毫升）。在患有败血症的婴儿中，纤连蛋白浓度在第1天显著下降（对照组为106（13）对173（18）微克/毫升），并在第2天仍显著低于对照组（123（26）对201（17）微克/毫升）。到第5天，纤连蛋白浓度升高，与对照组不再有统计学差异。纤连蛋白是免疫反应的关键调节因子，在中性粒细胞黏附、细菌调理作用、T细胞活化和血管完整性方面具有重要功能。早产儿败血症期间血浆纤连蛋白的急性消耗可能会进一步削弱他们控制败血症的能力。
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