Topaloglu A K, Hallioglu O, Duzovali O, Amac A, Yilgor E
Mersin University, Faculty of Medicine, Department of Pediatrics, Turkey.
Pediatr Int. 2001 Feb;43(1):26-8. doi: 10.1046/j.1442-200x.2001.01328.x.
Fibronectin (FN) is known to have important roles in host defense against infection. The risk for neonatal sepsis increases with the degree of immaturity of the host. Conflicting results have been reported on the relationship between plasma FN levels and gestational age (GA) in the preterm neonate.
In the present study, we determined plasma FN concentrations with an immunodiffusion method in 40 newborns of various gestational ages, ranging from 30 to 42 weeks.
We found a strong direct correlation between plasma FN levels and GA (r = 0.86; P < 0.001).
We speculate that the increased risk for neonatal sepsis with degree of prematurity may, in part, be explained by impaired defense with decreasing plasma FN levels seen with lessening GA.
已知纤连蛋白（FN）在宿主抗感染防御中发挥重要作用。新生儿败血症的风险随着宿主不成熟程度的增加而升高。关于早产儿血浆FN水平与胎龄（GA）之间的关系，已有相互矛盾的报道。
在本研究中，我们采用免疫扩散法测定了40例胎龄在30至42周之间的不同胎龄新生儿的血浆FN浓度。
我们发现血浆FN水平与GA之间存在很强的正相关（r = 0.86；P < 0.001）。
我们推测，随着早产程度增加，新生儿败血症风险增加，部分原因可能是随着GA减小，血浆FN水平降低，导致防御功能受损。
