Department of Oncological Sciences, 1425 Madison Avenue, Mount Sinai School of Medicine, New York, NY 10029, USA.
Immunity. 2011 Sep 23;35(3):323-35. doi: 10.1016/j.immuni.2011.09.007.
Macrophage and dendritic cell (DC) are hematopoietic cells found in all tissues in the steady state that share the ability to sample the environment but have distinct function in tissue immunity. Controversies remain on the best way to distinguish macrophages from DCs in vivo. In this Perspective, we discuss how recent discoveries in the origin of the DC and macrophage lineage help establish key functional differences between tissue DC and macrophage subsets. We also emphasize the need to further understand the functional heterogeneity of the tissue DC and macrophage lineages to better comprehend the complex role of these cells in tissue homeostasis and immunity.
巨噬细胞和树突状细胞(DC)是在稳态下存在于所有组织中的造血细胞,它们都具有采样环境的能力,但在组织免疫中具有不同的功能。关于如何在体内最好地区分巨噬细胞和 DC 仍然存在争议。在本观点中,我们讨论了 DC 和巨噬细胞谱系起源的最新发现如何有助于确定组织 DC 和巨噬细胞亚群之间的关键功能差异。我们还强调需要进一步了解组织 DC 和巨噬细胞谱系的功能异质性,以更好地理解这些细胞在组织稳态和免疫中的复杂作用。