Brain Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Toxicol Lett. 2011 Nov 30;207(2):191-6. doi: 10.1016/j.toxlet.2011.09.008. Epub 2011 Sep 16.
Increased use of ketamine as a recreational drug in rave party has raised lots of social concerns. Although its toxicity on the central nervous system (CNS) and urinary system had been reported, its potential adverse effects on the heart is still not addressed. Using our long term ketamine addiction model in which, 1-month-old ICR mice were given ketamine intraperitoneally (i.p. 30 mg/kg) for different study periods (6 weeks, 16 weeks and 28 weeks). The electrocardiogram (ECG) and the level of troponin as well as the presence of lactate dehydrogenase were used together to determine the cardiac function of mice. ST elevations were observed in 30% of mice from 6 weeks onwards. Concomitant increase in troponin in serum and presence of lactate dehydrogenase positive cardiac cells were taken together to indicate cardiac damages. The potential interactive effects of alcohol (ethanol) and ketamine were also addressed and 0.5 ml of 10% ethanol was administrated additionally to the mice daily and orally for the last 4 weeks in the 28-week long-term ketamine treated animals. The cardiac functions of these mice deteriorated more severely as indicated by further rise in troponin levels. In addition, high number of lactate dehydrogenase positive cardiac cells and abnormal ECGs in both ketamine and ketamine plus alcohol treated models also gave coherent conclusions.
在狂欢派对中，氯胺酮作为一种消遣性药物的使用越来越多，引起了很多社会关注。尽管已经报道了其对中枢神经系统（CNS）和泌尿系统的毒性，但它对心脏的潜在不良影响仍未得到解决。我们使用长期氯胺酮成瘾模型，其中 1 个月大的 ICR 小鼠经腹腔内（i.p. 30mg/kg）给予不同研究期的氯胺酮（6 周、16 周和 28 周）。心电图（ECG）和肌钙蛋白水平以及乳酸脱氢酶的存在一起用于确定小鼠的心脏功能。从 6 周开始，30%的小鼠出现 ST 抬高。同时血清肌钙蛋白升高和乳酸脱氢酶阳性心肌细胞的存在表明存在心脏损伤。还解决了酒精（乙醇）和氯胺酮的潜在相互作用，并在 28 周长程氯胺酮处理动物的最后 4 周，每天向小鼠额外口服给予 0.5ml10%乙醇。这些小鼠的心脏功能恶化得更严重，表明肌钙蛋白水平进一步升高。此外，在氯胺酮和氯胺酮加乙醇处理模型中，乳酸脱氢酶阳性心肌细胞数量增加和心电图异常也给出了一致的结论。
