Le Bras J, Ringwald P
Centre National de référence de la chimiosensibilité du paludisme, Hôpital Claude Bernard, Paris.
Med Trop (Mars). 1990 Jan-Mar;50(1):11-6.
Between 1978 and 1989, some Plasmodium falciparum chloroquino-resistant (C.Q.R.) strains have been imported in all intertropical African countries. Evidence of sudden occurrence of C.Q.R. foci was obtained by some prophylactic or therapeutic failures, and culture of strains from non-immune travellers back in Europe or U.S.A., then by carrying out some field surveys. C.Q.R. heterogeneity is the rule in Africa, efficiency of other antimalarial drugs diminishes rapidly in the foci where C.Q.R. remains at high level, probably in relation with drug pressure. Non typical clinical manifestations raising of child death-rate death not avoidable by chloroquino-prophylaxis, confused therapeutic attitudes were all of them the main facts accompanying the occurrence of C.Q.R. in Africa. It is not possible nowadays to foresee the evolution of C.Q.R. situation and of its social consequences in low-immune African populations.
1978年至1989年间，所有非洲热带国家都输入了一些耐氯喹恶性疟原虫（C.Q.R.）菌株。通过一些预防或治疗失败病例、对从欧洲或美国返回的非免疫旅行者的菌株进行培养，然后开展一些实地调查，获得了耐氯喹病灶突然出现的证据。耐氯喹异质性在非洲是常态，在耐氯喹水平仍较高的病灶中，其他抗疟药物的疗效迅速降低，这可能与药物压力有关。非典型临床表现、儿童死亡率上升、氯喹预防无法避免的死亡、混乱的治疗态度，这些都是非洲出现耐氯喹现象时伴随的主要情况。如今，无法预见耐氯喹情况及其在低免疫力非洲人群中的社会后果的演变。
